Integrins, Oncogenes, and Anchorage Independence
نویسندگان
چکیده
منابع مشابه
Integrins, Oncogenes, and Anchorage Independence
proteins, termed anchorage independence of growth, correlates closely with tumorigenicity in animal models (14). This property of cancer cells presumably reflects the tendency of tumor cells to survive and grow in inappropriate locations in vivo. Such incorrect localization, as occurs in invasion and metastasis, is the characteristic that distinguishes malignant from benign tumors (31). Great p...
متن کاملCross-talk between integrins and oncogenes modulates chemosensitivity.
Chemotherapy often relies on cancer cell death resulting from DNA damage. The p53 tumor suppressor pathway that is an important player in DNA damage response is frequently inactivated in cancer. Genotoxicants also activate DNA damage-independent stress pathways and activity of oncogenic signaling and adhesive interactions with the cancer microenvironment can have a strong impact on chemosensiti...
متن کاملEnergy Metabolism during Anchorage-Independence. Induction by Osteopontin-c
The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin, the shortest of which (osteopontin-c) supports anchorage-independence. Osteopontin-c signaling upregulates three interdependent pathways of the energy metabolism. Glutathione, glutamine and glutamate su...
متن کاملCharacterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele.
Treatment of diploid human fibroblasts with an alkylating mutagen has been shown to induce stable, anchorage-independent cell populations at frequencies (11 X 10(-4) consistent with an activating mutation. After treatment of human foreskin fibroblasts with the mutagen benzo[a]pyrene (+/-)anti- 7,8-dihydrodiol 9,10-epoxide and selection in soft agar, 17 anchorage-independent clones were isolated...
متن کاملGirth, minimum degree, independence, and broadcast independence
An independent broadcast on a connected graph $G$is a function $f:V(G)to mathbb{N}_0$such that, for every vertex $x$ of $G$, the value $f(x)$ is at most the eccentricity of $x$ in $G$,and $f(x)>0$ implies that $f(y)=0$ for every vertex $y$ of $G$ within distance at most $f(x)$ from $x$.The broadcast independence number $alpha_b(G)$ of $G$is the largest weight $sumlimits_{xin V(G)}f(x)$of an ind...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1997
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.139.3.575